The Potential Role of Mass Spectrometry in the Diagnosis of Immune-Related Diseases

  • Wanyin Cao Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Article ID: 191
DOI: https://doi.org/10.65533/med.v2i1.191
关键词: Mass spectrometry;Immune-Related diseases;Biomarkers;Diagnosis; Proteomics

摘要

Mass spectrometry (MS) has emerged as a powerful analytical technique with signiffcant potential for advancing the diagnosis of immune-related diseases. This comprehensive review examines the fundamental principles of MS technology and its diverse applications in autoimmune disorders, neuroimmune conditions, and cancer-related immune diseases. Through detailed analysis of recent research, we demonstrate how MS-based approaches enable precise characterization of autoimmune antibodies, identiffcation of novel biomarkers, and insights into disease mechanisms. The exceptional sensitivity and speciffcity of MS techniques facilitate detection of low-abundance proteins, post-translational modiffcations, and complex immune signatures that traditional methods often miss.

参考

[1]Dasgupta A ,Woodard K ,Ramoo B , et al. Technical Note: Signiffcant Positive Bias in Lower Concentrations but Negative Bias in Higher Concentrations in Testosterone Measurement Using Beckman Access Immunoassay Compared to a Liquid Chromatography-Tandem Mass Spectrometry Reference Method.[J].Annals of clinical and laboratory science,2024,54(2):258-261.
[2]J D H ,Graham J ,Dorothy K , et al. Evaluation of testosterone, estradiol and progesterone immunoassay calibrators by liquid chromatography mass spectrometry.[J].Clinical chemistry and laboratory medicine,2023,61(9):1612-1618.
[3]H L C ,Reuben M ,J N M . Human antibody profiling technologies for autoimmune disease.[J].Immunologic research,2023,71(4):516-527.
[4]CHH L ,Dragana N ,T N W . Interactome Profiling of DNA Damage Response (DDR) Mediators with Immunoprecipitation-Mass Spectrometry.[J].Methods in molecular biology (Clifton, N.J.),2023,2701185-197.
已出版
2026-01-03
期
卷 2 编号 1 (2026)
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