The Potential Role of Mass Spectrometry in the Diagnosis of Immune-Related Diseases

  • Wanyin Cao Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Article ID: 191
DOI: https://doi.org/10.65533/med.v2i1.191
Keywords: Mass spectrometry;Immune-Related diseases;Biomarkers;Diagnosis; Proteomics

Abstract

Mass spectrometry (MS) has emerged as a powerful analytical technique with signiffcant potential for advancing the diagnosis of immune-related diseases. This comprehensive review examines the fundamental principles of MS technology and its diverse applications in autoimmune disorders, neuroimmune conditions, and cancer-related immune diseases. Through detailed analysis of recent research, we demonstrate how MS-based approaches enable precise characterization of autoimmune antibodies, identiffcation of novel biomarkers, and insights into disease mechanisms. The exceptional sensitivity and speciffcity of MS techniques facilitate detection of low-abundance proteins, post-translational modiffcations, and complex immune signatures that traditional methods often miss.

References

[1]Dasgupta A ,Woodard K ,Ramoo B , et al. Technical Note: Signiffcant Positive Bias in Lower Concentrations but Negative Bias in Higher Concentrations in Testosterone Measurement Using Beckman Access Immunoassay Compared to a Liquid Chromatography-Tandem Mass Spectrometry Reference Method.[J].Annals of clinical and laboratory science,2024,54(2):258-261.
[2]J D H ,Graham J ,Dorothy K , et al. Evaluation of testosterone, estradiol and progesterone immunoassay calibrators by liquid chromatography mass spectrometry.[J].Clinical chemistry and laboratory medicine,2023,61(9):1612-1618.
[3]H L C ,Reuben M ,J N M . Human antibody profiling technologies for autoimmune disease.[J].Immunologic research,2023,71(4):516-527.
[4]CHH L ,Dragana N ,T N W . Interactome Profiling of DNA Damage Response (DDR) Mediators with Immunoprecipitation-Mass Spectrometry.[J].Methods in molecular biology (Clifton, N.J.),2023,2701185-197.
Published
2026-01-03
Issue
Vol. 2 No. 1 (2026)
Section
Articles

Yibo Research & Academic Press is committed to safeguarding authors' copyrights and all related information, ensuring these rights are fully protected by law. Whether you choose to publish your articles with our press or not, we require every employee to adhere to the highest ethical standards in the industry, assume responsibilities, and fulfill legal obligations.

To further protect authors' rights, we provide detailed information on copyright agreements on our official website for your reference. Regarding the reuse rights of articles, Yibo Research & Academic Press maintains an open attitude and strictly complies with the CC BY-NC 4.0 publication guidelines. This guideline not only provides copyright protection for authors but also meets the standards for usage rights set by the Open Access Scholarly Publishing Association (OASPA).

For authors who wish to further protect their articles, we also offer the CC BY-NC guideline service. Based on the CC guideline selected by the author, the original copyright and reuse rights of the article will be clearly stated in the article. This approach not only respects the authors' intellectual property rights but also promotes the reasonable dissemination and use of academic achievements.